Effects of Gynura procumbens Leaf Based Meal on Glucose Level, Lipid Profile and Mineral Content of Alloxan-Induced Diabetic Mice

Abstract

Gynura procumbens (GP) leaf is used as an anti-diabetic medicinal plant at Southeast Asia. A 28 day feeding trial was conducted to evaluate the effects of Gynura procumbens leaf meal on growth performance, glucose level, lipid profile and mineral content on alloxan- induced diabetic mice. A total of 36 mice at 14 days old were assigned to four treatment groups: NC (Normal Control), T0 Control (Basal diet), T1 (Basal diet + 0.5% Dry leaf on DM basis), T2 (Basal diet + 1.0% Dry leaf on DM basis) having 3 replications consisting of 9 mice each in a completely randomized design. The results revealed that glucose level were significantly (P<0.001) controlled at the last 3 weeks when compared to control and normal groups. There were no significant variations for blood Phosphorus, Ca and total protein. Three weeks dietary supplementation of GP leaf at feed 0.5% and 1.0% significantly (P<0.05) changes of bodyweights, water consumption and feed consumption of alloxan-induced diabetic mice. Other biochemical parameters like cholesterol, triglycerides, low density lipoproteins (LDL), high density lipoproteins (HDL) were found to be significantly (P<0.001) improved after treatment. Moreover, in the proximate CHO, crude protein, crude fat increased while ash, moisture, crude fiber decreased at treatment groups compared to basal diet. Overall, Gynura procumbens leaf showed trustworthy result on anti-diabetic effect included lipid profile.