Please use this identifier to cite or link to this item: http://dspace.cvasu.ac.bd/jspui/handle/123456789/817
Title: EFFECT OF OKRA (Abelmoschus esculentus) MUCILAGE ON GLUCOSE LEVEL AND LIPID PROFILE OF ALLOXAN-INDUCED DIABETIC MICE
Authors: Zim, A.F.M Irfan Uddin
Keywords: Okra, Mucilage, Antidiabetic, Anti-hyperlipidemic, Antiox
Issue Date: Jun-2019
Publisher: Chattogram Veterinary & Animal Sciences University
Abstract: The raw mucilage of okra (Abelmoschus esculentus) has been used for the management of diabetes mellitus in many rural part of Bangladesh. However, there is dearth of knowledge about the efficiency of it. Hence, this study aimed to explore antidiabetic, anti-lipidemic activity of crude okra mucilage powder. In addition, the effectiveness of okra mucilage was compared with the isolated peel-seed of Abelmoschus esculentus after mucilage extraction. Crude protein and mineral contents and antioxidant activity of the sample were also assessed. The protein content of okra mucilage and peel-seed powder was found at 8.54±0.96 g/100g and 11.28±1.27 g/100g respectively. The mineral concentrations for okra mucilage and peel-seed mixture showed high amount of calcium, magnesium, phosphorus, potassium, sodium and iron. Three weeks administration of crude mucilage and peel-seed suspensions at a dose of 150 mg/kg and 200mg/kg significantly (P<0.05) reversed the abnormal changes of bodyweights, water consumption, feed consumption and fasting blood glucose levels of alloxan induced diabetic mice. The other biochemical parameters like cholesterol, triglycerides, low density lipoproteins, high density lipoproteins, and total protein were found to be significantly (P<0.05) improved after mucilage and peel-seed treatment. In vitro antioxidant activity of the mucilage and peel-seed powder were determined by the DPPH free radical scavenging assay, total phenol content and total flavonoid content. For the antioxidant activity, the IC50 value was 73.83 μg/ml for okra mucilage and 67.09 μg/ml for peel-seed mixture. Quantitative analysis displayed 65.98±0.3 mg gallic acid equivalent (GAE)/g and 68.84±0.3 mg GAE/g for phenolic contents and 9.50± 1.1 mg quercetin equivalent (QE)/g and 7.90±0.1 mg QE/g for flavonoid contents for peel-seed mixture and mucilage respectively. Finally, okra mucilage showed less efficacy in terms of improving diabetic status as well as in vitro antioxidant activity compared to peel-seed mixture.
URI: http://dspace.cvasu.ac.bd/jspui/handle/123456789/817
Appears in Collections:Thesis-MS

Files in This Item:
File Description SizeFormat 
My thesis.pdf1.75 MBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.