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Authors: Ismat Ara Begum, Ismat Ara
Keywords: Gracilaria changii, bioactive peptides, in silico, DPP-IV inhibitor, ACE inhibitor.
Issue Date: Dec-2020
Publisher: Chattogram Veterinary and Animal Sciences University Chattogram-4225, Bangladesh
Abstract: Gracilaria changii is an agarophytic red seaweed mostly found in mangroves. Previous resarchers indicated that Gracilaria changii possess high protein(12.57 % of dry weight). So, its proteins are potential precursors for relasing bioactive peptides. To date, no study has been reported on the evaluation of Gracilaria changii proteins as a precursors of bioactive peptides. In the present study, bioactive peptides in phycocyanin alpha subunit(protein) of Gracilaria changii was evaluated based on in silico approach. In silico analysis of phycocyanin alpha subunit exhibited in high numbers of bioactive peptides predominately with dipeptidylpeptiase -IV(DPP-IV) inhibitory peptides and angiotensin-I-converting enzyme (ACE-I) inhibitory peptides having lower EC50 value. Other bioactive peptides are DPP III inhibitor, antioxidative, Renin inhibitor , alpha glucosidase inhibitor and neuropeptide. The application of silico tools provided rapid identification of protein. Overall, this study highlighted the potentiality of phycocyanin alpha subunit as a raw ingredient for developing pharmaceuticals products or functional foods
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