Please use this identifier to cite or link to this item: http://dspace.cvasu.ac.bd/jspui/handle/123456789/1702
Title: IN SILICO EVALUATION OF BIOACTIVE PEPTIDES FROM PYROPIA ORBICULARIS
Authors: ISLAM, MD IMRANUL
Keywords: ACE inhibitor , DPP IV inhibitor ,Pyropia orbicularis, Bioactive peptides, in silico
Issue Date: Aug-2022
Publisher: Chattogram Veterinary & Animal |Sciences University
Abstract: ome of the proteins in pyropia orbiculars could serve as starting points for creating bioactive peptides. Peptides as a structural component of bioactive proteins In this virtual experiment, selected 12 proteins from the pyropia orbicularis. perfornrd as potential precursors to bioactive peptides. The most promising bioactivities were found to be those that inhibited dipeptidyl peptidase-IV (DPP IV) and angiotensinconverting enzyme (ACE). Papain, thermolysin, and stem bromelain were all used for in-silico proteolysis. For this reason, 63 different tripeptides or novel peptides were tested to see if any of them could be considered novel bioactive peptides. PeptideRanker, PepCalc, Peptide Cutter, ToxinPred, AllerTop, and AHTpin were also utilized in order to investigate the peptides' unique characteristics. The bioinformatics tools predicted that most of all the peptides were safe to use, and an additional 28 were predicted to be non-allergenic and highly promising. These findings provide support for using pyropia orbicularis as a source of bioactive peptides and lay the groundwork for further in-vitro and in-vivo research into these compounds.
URI: http://dspace.cvasu.ac.bd/jspui/handle/123456789/1702
Appears in Collections:Thesis-MS

Files in This Item:
File Description SizeFormat 
combinepdf imran.pdf1.8 MBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.