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Title: Determination of Strong Ion Difference and Anion Gap from blood biochemical parameters in Lactating Cow
Authors: Islam, Rakibul
Keywords: Strong ions, strong ion differences, anion gap
Issue Date: Nov-2021
Publisher: Chattogram Veterinary and Animal Sciences University Khulshi, Chattagram-4225, Bangladesh
Abstract: The objectives of this study are to determine serum strong ion differences (SID) and anion gap (AG) of 8 high yielding lactating dairy cows with a history of inappetence and drop of milk production. Blood biochemical data of 8 cows were collected from diagnostic reports done at the Department of Physiology, Biochemistry and Pharmacology, Chattogram Veterinary and Animal Sciences University. Concentrations of quantitatively important strong ions (Na+, K+, Ca2+, Mg2+, Cl-) and nonvolatile buffer ions (total protein and phosphate) were determined and a fixed L-lactate value was used. Mean (±SD) of Strong ion difference (SID) was determined by calculating the differences between measured strong anion and cation concentrations (SID3, 37.56 mEq/L; SID4, 37.02 mEq/L; SID6, 40.14 mEq/L). Mean value of Atot, total plasma concentration of nonvolatile weak acids was calculated (Atot, 28.10 mmol/L) and this value along with a fixed value of Ka, effective dissociation constant for plasma weak acids and pH is then used to calculate concentrations of HCO3-. Anion Gap is then determined and the mean value of anion gap (AG) is 16.62 mEq/L, which is within the normal reference range. Although acid-base abnormalities are frequently present in sick animals. Measuring SID and AG will not only help in explaining the underlaying disease mechanisms of Acid-base disorders but also will help in proper treatment protocols.
Appears in Collections:Clinical Report

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