COMPARISON OF ANESTHETIC POTENCY AND CARDIOPULMONARY EFFECTS OF HALOTHANE AND ISOFLURANE ANESTHESIA IN SMALL

Abstract

This study compared the anesthetic potency and cardiopulmonary effects between halothane and isoflurane in 20 goats during routine surgery. The goats were randomly divided into two groups: HAL (n=10) and ISO (n=10), premedicated with diazepam (0.5mg/kg) intravenously, and induced by propofol (3mg/kg). Anesthesia was maintained either with halothane or isoflurane in oxygen at a total gas flow rate of 20ml/kg/min. During surgery heart rate, respiratory rate, non-invasive blood pressure, rectal temperature and oxygen hemoglobin saturation were monitored and recorded. According to the patient’s response (such as blood pressure, eye position, respiratory and heart rate) to surgical stimulation, anesthetic concentration was adjusted. At the recovery stage, first head movement, sternal recumbency, ability to stand up were observed and recorded. Rapid and smooth recoveries were found in isoflurane anesthesia in comparison to halothane. Heart rate, rectal temperature, systolic arterial pressure, diastolic arterial pressure and mean arterial pressure were decreased significantly (p <0.05) in HAL group. There was no significant (p>0.05) differences comparing respiratory rate and oxygen saturation between the two groups. From this study, it was determined that isoflurane anesthesia in small ruminants provides a shorter and safer recovery with maximum preservation of cardiovascular and pulmonary functions. Therefore, isoflurane anesthesia can be preferred to halothane for routine anesthesia in small ruminants.