ASSESSMENT OF BIOCHEMICAL ALTERATION OF ASPERGILLOSIS AFFECTED BROILERS TREATED WITH MEDICINAL PLANT EXTRACTS AND SYNTHETIC ANTIFUNGALS

Abstract

An experimental case-control study had been undertaken to evaluate the biochemical alteration and productive performance of aspergillosis affected broilers while treated with medicinal plant extracts and synthetic antifungals. The study was conducted during June to December 2014 under the Department of Physiology, Biochemistry and Pharmacology, Chittagong Veterinary and Animal Sciences University, Bangladesh. Experimentally, 150 cobb-500 strain broilers were reared from day 0 to day 30 with proper broiler management. According to treatment intervention, seven bird groups (T0-T6) designed as control, onion, garlic, neem, tulsi, 0.1% CuSO4 and Nystatin Sulphate where each group consists of 21 birds. At day 16 and day 20, Aspergillus infection was introduced through feed and water and manifesting signs were recorded. After the signs, treatment was started accordingly and continued for 6 days. For determining biochemical alteration, blood sample was collected at infection exposure, during treatment and post treatment period. At the time of infection, significant changes (p ≤0.05) was observed on albumin, aspartate aminotransferase (AST), triglycerides (TG) while during treatment significant adjustment was found only on AST level. After the treatment, significant alteration was also prevailed on albumin, alanine aminotransferase (ALT) and high density lipoprotein (HDL). In groups, significant changes were pragmatic on glucose, AST, HDL in neem group; albumin, TG, low density lipoprotein (LDL) in garlic group; AST in onion; HDL in 0.1% CuSO4 and albumin, cholesterol in control group. It was evident that, though infection was retardated the growth and slowly hampered various organs but broilers had a better weight gain with a lower feed conversion ratio (FCR) as well as good productive performance in garlic group comparing to control group.